Answer
Aciclovir triphosphate, the active triphosphate metabolite of valaciclovir hydrochloride, competitively inhibits viral DNA polymerase, and its incorporation into viral DNA causes obligate chain termination, halting DNA synthesis and blocking viral replication.
Sources for this answer
- Valtrex Tablets 500mgGlaxoSmithKline UK · emc · SmPC §5.1 Pharmacodynamic properties · Version 32Document updated
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