Answer
During valaciclovir hydrochloride treatment, probenecid reduces aciclovir renal clearance by inhibiting its active renal secretion; following 1000 mg valaciclovir, it increases aciclovir exposure (AUC) by about 45%.
Sources for this answer
- Valtrex Tablets 500mgGlaxoSmithKline UK · emc · SmPC §4.5 Interaction with other medicinal products · Version 32Document updated
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