Answer
Tafamidis binds to the thyroxine binding sites on transthyretin, stabilising its tetramer and slowing dissociation into monomers, the rate-limiting step in the amyloidogenic process.
Sources for this answer
- Vyndaqel 61 mg soft capsulesPfizer Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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