tafamidis · Medicine question

Can tafamidis interact with methotrexate through inhibition of the BCRP transporter?

Name: Can tafamidis interact with methotrexate through inhibition of the BCRP transporter?
Published: 2026-11-08T02:04:40.508Z

iatroX medicinesPublished 8 November 2026

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Tafamidis inhibits BCRP in vitro at the 61 mg/day dose and may interact at clinically relevant concentrations with BCRP substrates such as methotrexate.

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Vyndaqel 61 mg soft capsulesPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 6Document updated 1 March 2023

Sources checked 8 November 2026

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