Answer
Tacrolimus in Protopic ointment binds FKBP12, inhibiting calcium-dependent T-cell signalling and thereby preventing cytokine transcription and synthesis, including IL-2, IL-3, IL-4 and IL-5; its mechanism in atopic dermatitis is not fully understood, and the clinical significance of these observations is unknown.
Sources for this answer
- Protopic 0.1% ointmentLeo Laboratories Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 23Document updated
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