Answer
St John's wort may decrease ivabradine exposure and activity through CYP3A4 induction; with ivabradine 10 mg twice daily, it reduced ivabradine AUC by half, and its intake should be restricted during ivabradine treatment.
Sources for this answer
- Ivabradine 5 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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