Answer
Sitagliptin inhibits DPP-4, increasing active incretin hormones GLP-1 and GIP, which increase insulin release and decrease glucagon in a glucose-dependent manner, reducing glucose production by the liver and lowering blood glucose.
Sources for this answer
- JANUVIA 25mg, 50mg, 100mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 32Document updated
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