Answer
With digoxin 0.25 mg and sitagliptin 100 mg daily for 10 days, digoxin exposure (AUC) increased by 11% and peak concentration by 18% on average; no digoxin dose adjustment is recommended, but patients at risk of digoxin toxicity should be monitored.
Sources for this answer
- JANUVIA 25mg, 50mg, 100mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 32Document updated
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