Answer
Seladelpar activates PPAR receptors, reducing liver bile acid synthesis through fibroblast growth factor 21 (FGF21)-dependent downregulation of CYP7A1, the key enzyme converting cholesterol into bile acids, and by decreasing cholesterol synthesis and absorption.
Sources for this answer
- Livdelzi 10 mg capsulesGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 5Document updated
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