Answer
Rifampicin strongly induces CYP2C19, increasing clopidogrel’s active metabolite levels and platelet inhibition, which may increase bleeding risk, so concomitant use is discouraged as a precaution.
Sources for this answer
- Rifadin For Infusion 600mgSANOFI · emc · SmPC §4.5 Interaction with other medicinal products · Version 32Document updated
Sources checked