Answer
Rifampicin reduces tolvaptan peak concentration (Cmax) and total exposure (AUC) by about 85%, decreasing its effectiveness, so concomitant administration should be avoided.
Sources for this answer
- Jinarc 15mg TabletsOtsuka Pharmaceuticals (UK) Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 17Document updated
Sources checked