pemigatinib · Medicine question

How does rifampicin affect pemigatinib exposure?

iatroX medicinesPublished 8 November 2026

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Rifampicin (rifampin) 600 mg once daily, a strong CYP3A4 inducer, decreased pemigatinib geometric mean AUC by 85% (90% CI: 84%–86%), potentially reducing pemigatinib efficacy.

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Pemazyre 4.5 mg - tabletsIncyte Biosciences UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated 3 February 2026

Sources checked 8 November 2026

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