Answer
In a study of 16 healthy adult men, rifampicin reduced linezolid peak concentration (Cmax) by a mean 21% and overall exposure (AUC) by a mean 32%; the interaction’s mechanism and clinical significance are unknown.
Sources for this answer
- Zyvox 2 mg/ml Solution for InfusionPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated
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