Answer
Pretreatment with rifampicin 600 mg once daily for 7 days decreased afatinib exposure by 34% (AUC0-∞) and 22% (Cmax) after a single 40 mg dose of Giotrif (afatinib dimaleate).
Sources for this answer
- Giotrif 20 mg film-coated tabletsBoehringer Ingelheim Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
Sources checked