protamine sulfate · Medicine question

How does protamine sulfate neutralise heparin?

iatroX medicinesPublished 8 November 2026

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Protamine sulfate’s precise mechanism is unknown, but strongly basic protamine combines with strongly acidic heparin to form a stable salt lacking anticoagulant activity.

Sources for this answer

Prosulf 10mg/ml Solution for InjectionWockhardt UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated 9 May 2018

Sources checked 8 November 2026

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