Answer
Although guanfacine's mechanism in ADHD is not fully established, preclinical research suggests it modulates signalling in the prefrontal cortex and basal ganglia by directly modifying synaptic noradrenalin transmission at alpha-2A adrenergic receptors.
Sources for this answer
- Intuniv 4 mg prolonged-release tabletsTakeda UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated
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