Answer
When taken with Intuniv (guanfacine), ketoconazole increased guanfacine peak plasma concentrations twofold and overall exposure threefold in adult interaction studies, with similar outcomes expected in the indicated paediatric age range.
Sources for this answer
- Intuniv 4 mg prolonged-release tabletsTakeda UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
Sources checked