Answer
Alimta (pemetrexed disodium) disrupts folate-dependent processes essential for cell replication by inhibiting thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, enzymes needed to synthesise thymidine and purine nucleotides, as shown in vitro.
Sources for this answer
- Alimta 100mg and 500mg powder for concentrate for solution for infusionEli Lilly and Company Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 29Document updated
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