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Medicines pemetrexed disodiumQuestion & answer

pemetrexed disodium · Medicine question

How does probenecid interact with pemetrexed disodium?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Probenecid, an OAT3 inhibitor, delays pemetrexed disodium clearance when used concomitantly, so the combination requires caution.

Sources for this answer

Alimta 100mg and 500mg powder for concentrate for solution for infusionEli Lilly and Company Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 29Document updated 27 February 2026

Sources checked 8 November 2026

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pemetrexed disodium

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