moclobemide · Medicine question

How does moclobemide work as an antidepressant?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Moclobemide (Manerix) reversibly inhibits monoamine oxidase, preferentially type A, reducing the breakdown of noradrenaline, dopamine and serotonin and increasing their extracellular concentrations in the brain.

Sources for this answer

Manerix 300mgViatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated 25 March 2026

Sources checked 8 November 2026

Explore this learning need in CPDTake this topic to CPD, then choose your learning context and available question library.

Does moclobemide pass into breast milk?Has the safety of moclobemide (Manerix) in human pregnancy been established?How can moclobemide affect omeprazole exposure?Is moclobemide (Manerix) used to treat major depression in adults?Is taking tramadol with moclobemide contraindicated?What are the very common side effects of moclobemide (Manerix)?

loading page…

Answer

Sources for this answer

More questions about moclobemide

Answer

Sources for this answer

More questions about moclobemide

moclobemide

More clinical questions?