Answer
Mitoxantrone hydrochloride intercalates into DNA through hydrogen bonding, causing crosslinks and strand breaks, and potently inhibits topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA.
Sources for this answer
- Onkotrone Injection 2 mg/ml concentrate for solution for infusionBaxter Healthcare Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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