How does mitotane affect warfarin metabolism?

Name: How does mitotane affect warfarin metabolism?
Published: 2026-11-08T01:57:00.711Z

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Mitotane has been reported to accelerate warfarin metabolism through hepatic microsomal enzyme induction, increasing warfarin dose requirements and necessitating close monitoring for changes in anticoagulant dose requirements.

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Mitotane Esteve 500 mg TabletsEsteve Pharmaceuticals (formerly Intrapharm Laboratories) · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated 23 June 2025

Sources checked 8 November 2026

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