Answer
Midazolam enhances GABA-mediated neurotransmission at inhibitory synapses through positive allosteric modulation that increases the GABA receptor’s affinity for GABA, thereby increasing released GABA’s action on postsynaptic transmembrane chloride ion flux.
Sources for this answer
- Midazolam 2 mg/ml, solution for injection / infusionhameln pharma ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated
Sources checked