How does ketoconazole affect the plasma concentration and half-life of intravenous midazolam?

Ketoconazole increases intravenous midazolam plasma concentrations fivefold and terminal half-life approximately threefold; coadministration requires an ICU or similar setting with close monitoring and management of respiratory depression or prolonged sedation, with staggered dosing and dosage adjustment considered, especially for repeated IV doses.