Answer
Metolazone increases urine production by blocking sodium reabsorption in the ascending branch of the loop of Henle and proximal tubules, leading to excretion of approximately equivalent amounts of sodium and chloride.
Sources for this answer
- Xaqua 5 mg TabletsRenascience Pharma Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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