lecanemab · Medicine question

How does lecanemab act on amyloid beta in the brain?

iatroX medicinesPublished 8 November 2026

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Lecanemab is a humanised IgG1 monoclonal antibody that binds selectively to aggregated amyloid beta, preferentially toxic soluble protofibrils, to neutralise and clear them from the brain, while showing low affinity for amyloid beta monomers.

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Leqembi 100 mg/mL concentrate for solution for infusionEisai Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 5Document updated 24 November 2025

Sources checked 8 November 2026

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What tests can confirm amyloid beta pathology before starting lecanemab?Can lecanemab be used during pregnancy?How is Leqembi (lecanemab) concentrate for solution for infusion administered?How long must women of childbearing potential use effective contraception during and after lecanemab treatment?Is it known whether lecanemab passes into human breast milk?What does Leqembi (lecanemab) concentrate for solution for infusion look like?

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