Answer
Studies suggest lamotrigine blocks voltage-gated sodium channels in a use- and voltage-dependent manner, inhibiting sustained repetitive nerve-cell firing and release of glutamate, a neurotransmitter involved in generating epileptic seizures, effects likely to contribute to seizure control.
Sources for this answer
- LamictalGlaxoSmithKline UK · emc · SmPC §5.1 Pharmacodynamic properties · Version 53Document updated
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