lamotrigine · Medicine question

How common is headache as a side effect of lamotrigine?

iatroX medicinesPublished 8 November 2026

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Headache is a very common side effect of lamotrigine, affecting at least 1 in 10 people, based on controlled studies in epilepsy monotherapy and bipolar disorder.

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LamictalGlaxoSmithKline UK · emc · SmPC §4.8 Undesirable effects · Version 53Document updated 19 November 2025

Sources checked 8 November 2026

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Which side effects of lamotrigine may affect driving or operating machinery?Are there any special disposal requirements for Lamictal (lamotrigine)?Can Lamictal (lamotrigine) be used as monotherapy for typical absence seizures in children aged 2 to 12 years?Does Lamictal (lamotrigine) require any special storage conditions?How can Lamictal (lamotrigine) chewable/dispersible tablets be administered?How does lamotrigine act on nerve cells to help control epileptic seizures?

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