Answer
Ketoconazole increases mefloquine hydrochloride plasma concentrations and elimination half-life, so QTc prolongation may occur if ketoconazole is taken during mefloquine malaria prevention or treatment, or within 15 weeks after the last mefloquine dose.
Sources for this answer
- Lariam 250 mg tablets / Mefloquine 250 mg tabletsNeon Healthcare Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 5Document updated
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