Answer
Itraconazole increases systemic exposure (AUCinf) to zuranolone by 62%, and the zuranolone dose should be reduced to 30 mg when used with this strong CYP3A inhibitor.
Sources for this answer
- Zurzuvae 20 mg, 25 mg and 30 mg Hard CapsulesBiogen Idec Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
Sources checked