inclisiran sodium · Medicine question

How does inclisiran sodium lower LDL cholesterol?

iatroX medicinesPublished 8 November 2026

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Inclisiran sodium uses RNA interference in liver cells to break down PCSK9 messenger RNA, increasing LDL receptor recycling and expression on liver cell surfaces, which increases LDL cholesterol uptake and lowers circulating LDL cholesterol.

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Leqvio 284 mg solution for injection in pre filled syringeNovartis Pharmaceuticals UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated 25 November 2025

Sources checked 8 November 2026

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Are clinically meaningful interactions expected between inclisiran sodium and atorvastatin or rosuvastatin?Has Leqvio (inclisiran sodium) been studied in patients with severe hepatic impairment?How much sodium does Leqvio (inclisiran sodium) contain per dose?What common adverse reactions are associated with Leqvio (inclisiran sodium)?What excipients are listed for Leqvio (inclisiran sodium) solution for injection in a pre-filled syringe?

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