Answer
Ibrutinib forms a covalent bond with the cysteine residue Cys-481 in the active site of Bruton's tyrosine kinase (BTK), producing sustained inhibition of BTK enzymatic activity.
Sources for this answer
- IMBRUVICA 140 mg film-coated tablets (Great Britain)Janssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §5.1 Pharmacodynamic properties · Version 25Document updated
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