How does fostemsavir tromethamine prevent HIV-1 from entering host cells?

Fostemsavir tromethamine is a prodrug without significant antiviral activity that is hydrolysed to temsavir, which binds directly to the gp120 subunit of HIV-1 envelope glycoprotein gp160 and selectively inhibits interaction with cellular CD4 receptors, preventing viral entry into and infection of host cells.