fluorouracil · Medicine question

How does fluorouracil inhibit DNA synthesis?

iatroX medicinesPublished 8 November 2026

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Answer

After intracellular conversion to its active deoxynucleotide, fluorouracil inhibits DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid by thymidylate synthetase.

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Fluorouracil 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 19Document updated 18 May 2026

Sources checked 8 November 2026

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