Answer
Factor VIII + von Willebrand factor replaces deficient factor VIII in haemophilia A, temporarily correcting bleeding tendencies by supporting factor IX-mediated activation of factor X, which generates thrombin and then clot-forming fibrin; von Willebrand factor also supports platelet adhesion and aggregation.
Sources for this answer
- Dried Factor VIII Fraction, type 8YBio Products Laboratory Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
Sources checked