evolocumab · Medicine question

How does evolocumab lower LDL cholesterol?

iatroX medicinesPublished 8 November 2026

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Evolocumab binds selectively to PCSK9, preventing it from binding to LDL receptors on liver cells and causing their degradation, thereby increasing liver LDL receptor levels and lowering blood LDL cholesterol.

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Repatha SureClickAmgen Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 21Document updated 15 July 2026

Sources checked 8 November 2026

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