Answer
Statins increase evolocumab clearance by approximately 20%, partly through increased PCSK9 concentrations, but this does not adversely affect evolocumab's lipid-lowering effect, and no statin dose adjustment is necessary when they are used together.
Sources for this answer
- Repatha SureClickAmgen Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 21Document updated
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