Esomeprazole · Medicine question

How does esomeprazole reduce stomach acid production?

iatroX medicinesPublished 8 November 2026

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Answer

Esomeprazole becomes active in the highly acidic secretory canaliculi of stomach parietal cells, where it inhibits H+K+-ATPase (the acid pump), reducing both basal and stimulated acid secretion.

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Nexium I.V. 40mg Powder for solution for injection/infusionAstraZeneca UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 27Document updated 10 July 2024

Sources checked 8 November 2026

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