Answer
Emtricitabine/tenofovir disoproxil inhibits HIV-1 replication through emtricitabine triphosphate and tenofovir diphosphate, formed by cellular phosphorylation after tenofovir disoproxil converts to tenofovir; these active metabolites competitively inhibit HIV-1 reverse transcriptase, causing DNA chain termination.
Sources for this answer
- Emtricitabine/Tenofovir disoproxil Dr. Reddy's 200 mg/245 mg Film-Coated TabletsDr. Reddy's Laboratories (UK) Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated
Sources checked