How does docetaxel act on microtubules?

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Docetaxel promotes tubulin assembly into stable microtubules and inhibits their disassembly, markedly decreasing free tubulin without altering protofilament numbers; in vitro, it disrupts the microtubular network essential for mitotic and interphase cellular functions.

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Docetaxel Hospira 10 mg/ml Concentrate for Solution for InfusionHospira UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated 2 September 2025

Sources checked 8 November 2026

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