docetaxel · Medicine question

How does ketoconazole affect the clearance of docetaxel?

iatroX medicinesPublished 8 November 2026

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Ketoconazole, a strong CYP3A4 inhibitor, significantly reduced docetaxel clearance by 49% when co-administered in a pharmacokinetic study involving seven patients.

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Docetaxel Hospira 10 mg/ml Concentrate for Solution for InfusionHospira UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated 2 September 2025

Sources checked 8 November 2026

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