Answer
Defibrotide reduces excessive activation of endothelial cells lining blood vessels, helps restore endothelial function and the balance between clotting and clot breakdown, and has antithrombotic, fibrinolytic, anti-adhesive and anti-inflammatory actions, although its exact mechanism is not fully understood.
Sources for this answer
- Defitelio 80 mg/mL concentrate for solution for infusionJazz Pharmaceuticals UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 14Document updated
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