Answer
Defitelio (defibrotide) should not be used during pregnancy unless the woman’s clinical condition requires it, as there are no studies in pregnant women and animal studies at doses close to the recommended human dose showed a high rate of haemorrhagic abortion.
Sources for this answer
- Defitelio 80 mg/mL concentrate for solution for infusionJazz Pharmaceuticals UK Limited · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 14Document updated
Sources checked