Answer
Daptomycin acts only against Gram-positive bacteria by binding, in the presence of calcium ions, to membranes of growing and stationary-phase cells, causing depolarisation and rapid inhibition of protein, DNA and RNA synthesis, resulting in bacterial death with negligible cell lysis.
Sources for this answer
- Cubicin powder for concentrate for solution for injection or infusionMerck Sharp & Dohme (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 26Document updated
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