clonazepam · Medicine question

How does clonazepam affect GABA signalling in the brain?

iatroX medicinesPublished 8 November 2026

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Clonazepam enhances inhibitory GABA signalling in the brain through positive allosteric modulation, increasing GABA receptor affinity for GABA and strengthening released GABA’s effect on postsynaptic chloride ion flux.

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Clonazepam Thame 0.5mg/5ml Oral SolutionSyriMed · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated 24 February 2023

Sources checked 8 November 2026

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