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Medicines clonazepamQuestion & answer

clonazepam · Medicine question

How can fluconazole affect clonazepam concentrations and effects?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Fluconazole inhibits CYP3A4 and may impair clonazepam metabolism, leading to increased clonazepam concentrations and exaggerated effects.

Sources for this answer

Clonazepam Rosemont 0.5mg/5ml Oral SolutionRosemont Pharmaceuticals Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated 17 April 2024

Sources checked 8 November 2026

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