Answer
Cenobamate positively allosterically modulates GABAA receptor subtypes without binding the benzodiazepine site and reduces repetitive neuronal firing by enhancing sodium-channel inactivation and inhibiting persistent sodium current; its precise therapeutic mechanism in focal-onset seizures is unknown.
Sources for this answer
- Ontozry 200 mg film-coated tabletsAngelini Pharma UK-I Limited (Formerly Arvelle Therapeutics UK) · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated
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