How does carbamazepine affect paliperidone exposure when taken with Invega prolonged-release tablets?

In adult interaction studies, carbamazepine 200 mg twice daily with once-daily Invega reduced paliperidone’s mean steady-state Cmax and AUC by approximately 37%, substantially through increased renal clearance; higher carbamazepine doses could cause larger decreases in paliperidone concentrations.