Answer
Brensocatib competitively and reversibly inhibits dipeptidyl peptidase 1 (DPP1), which activates pro-inflammatory neutrophil serine proteases during neutrophil maturation in bone marrow, thereby reducing the activity of proteases implicated in bronchiectasis, including neutrophil elastase, cathepsin G and proteinase 3.
Sources for this answer
- Brinsupri 25 mg film-coated tabletsInsmed Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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