Answer
In indapamide + perindopril, perindopril inhibits ACE, reducing angiotensin II formation, aldosterone secretion and peripheral resistance, while indapamide inhibits renal sodium reabsorption, increasing salt and water excretion, and improves arterial compliance and reduces vascular resistance, with synergistic blood-pressure-lowering effects.
Sources for this answer
- Coversyl arginine plus 5 mg/1.25 mg film-coated tabletsServier Laboratories Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated
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